Research Articles
Systematic Design of Periodic Antibiotic Dosing to Eradicate Bacterial Persisters
Persister cells, a dormant subpopulation of bacteria tolerant to conventional antibiotics, are a major cause of chronic and relapsing infections.
Advanced Scanning Electron Microscopy Protocols for High-Resolution Biofilm Visualization
This article provides a comprehensive guide to scanning electron microscopy (SEM) protocols for visualizing microbial biofilms, tailored for researchers and drug development professionals.
Optimizing Periodic Antibiotic Dosing: Strategies to Reduce Total Dosage and Combat Resistance
This article synthesizes current research and innovative methodologies for optimizing periodic antibiotic dosing regimens to significantly reduce total antibiotic usage without compromising efficacy.
LC-MS/MS Proteomics in Biofilm Research: From Fundamentals to Clinical Applications
This comprehensive review explores the transformative role of LC-MS/MS proteomics in analyzing biofilm-forming bacterial strains, addressing critical challenges in biomedical research and therapeutic development.
Microfluidics for Persister Cell Research: Single-Cell Analysis, Platforms, and Therapeutic Strategies
Bacterial persister cells, a subpopulation capable of surviving antibiotic treatment, are a major cause of chronic and relapsing infections.
Toxin-Antitoxin Modules in Bacterial Persistence: Mechanisms, Functions, and Therapeutic Targeting
This article provides a comprehensive analysis of the mechanisms by which bacterial toxin-antitoxin (TA) modules contribute to phenotypic persistence and antibiotic tolerance.
Agent-Based Modeling of Biofilm Persister Dynamics: From Mechanisms to Therapeutic Optimization
This article provides a comprehensive overview of agent-based modeling (ABM) for investigating biofilm persister cell dynamics, a major contributor to chronic infections and antimicrobial treatment failure.
Metabolic Heterogeneity in Bacterial Persisters: Mechanisms, Analysis, and Therapeutic Targeting
Bacterial persisters, a subpopulation of cells exhibiting transient antibiotic tolerance, are a major cause of relapsing and chronic infections.
The Stringent Response and ppGpp: Master Regulators of Bacterial Persister Cell Formation and Novel Therapeutic Targets
This article provides a comprehensive analysis of the pivotal role played by the alarmone (p)ppGpp and the stringent response in the formation of bacterial persister cells, a major cause of...
Comparative Virulence Assessment of Novel Bacterial Species: Genomic Strategies, Pathogenicity Profiling, and Therapeutic Implications
The rapid emergence of novel and often multidrug-resistant bacterial species poses a significant threat to public health, necessitating robust frameworks for their virulence assessment.