Research Articles
Evaluating Commercial Kits for Unidentified Bacteria: A Comprehensive Guide for Researchers and Developers
This article provides a systematic framework for researchers, scientists, and drug development professionals to evaluate and select commercial kits for identifying unknown bacterial isolates.
Optimizing Extraction Methods for Diverse Clinical Samples: From Foundational Principles to Advanced Applications
This article provides a comprehensive analysis of nucleic acid and bioactive compound extraction methodologies tailored for diverse clinical samples.
From Petri Dishes to Digital PCR: The Evolving Battlefield of Pathogen Discovery
This article provides a comprehensive comparison between traditional culture-based methods and modern molecular techniques for pathogen discovery and diagnostics.
Unseen Threats: Investigating the Spectrum of Diseases from Unrecognized Bacteria and the Frontier of Diagnostic Solutions
This article addresses the critical challenge of unidentified and misidentified bacterial pathogens, a growing concern for global public health and drug development.
Beyond Culture: Advanced Culture-Independent Methods for Rapid Pathogen Detection in Clinical and Food Safety Applications
This article provides a comprehensive overview of culture-independent methods for pathogen detection, critically evaluating their capacity to overcome the limitations of traditional culture-based techniques.
Uncultivated Bacterial Pathogens: Unveiling the Hidden Majority in Human Disease and Drug Discovery
This article synthesizes current knowledge on uncultivated bacteria, a vast reservoir of microbial diversity largely inaccessible through traditional laboratory methods.
Single vs. Multiple Growth Parameters for Medium Specialization: A Strategic Guide for Enhanced Selective Culture
This article explores the critical decision between using single and multiple growth parameters for medium optimization and specialization in biomedical research.
Bridging the Microbial Gap: A Comprehensive Comparison of Cultured and Total Bacterial Diversity Through High-Throughput Sequencing
This article synthesizes current research on the critical disparity between cultured and total bacterial diversity revealed by high-throughput sequencing (HTS).
Optimizing Nutrient Concentrations for Oligotrophic Bacteria: Advanced Cultivation Strategies for Pharmaceutical Research
Oligotrophic bacteria, adapted to low-nutrient environments, pose significant challenges for cultivation and detection in pharmaceutical quality control and drug development.
The Physiological Basis of the Viable But Non-Culturable (VBNC) State: Mechanisms, Detection, and Clinical Implications
This article comprehensively reviews the physiological basis for the induction of the viable but non-culturable (VBNC) state, a dormant survival strategy employed by bacteria under stress.