Research Articles
Probing Biofilm Dynamics in Liquid: How Physiological AFM is Revolutionizing Antimicrobial Research
This article explores the transformative role of Atomic Force Microscopy (AFM) performed under physiological, fluid conditions in advancing biofilm research.
AFM Cantilever Functionalization for Biofilm Receptor Studies: Protocols, Applications, and Advanced Techniques
This article provides a comprehensive resource for researchers and drug development professionals on functionalizing Atomic Force Microscopy (AFM) cantilevers to study specific receptor interactions within bacterial biofilms.
Nanomechanical Properties of Extracellular Polymeric Substances (EPS): From Fundamental Characterization to Advanced Drug Delivery Applications
This article provides a comprehensive analysis of the nanomechanical properties of Extracellular Polymeric Substances (EPS), a critical component of microbial biofilms and cellular matrices.
Efflux Pump Inhibitors as Biofilm Disruptors: Efficacy Validation and Strategies to Combat Antimicrobial Resistance
The escalating global crisis of antimicrobial resistance (AMR) is profoundly exacerbated by bacterial biofilms, which confer significant tolerance to conventional antibiotics.
Comparative Mechanisms of Bacterial Persister Formation: From Molecular Pathways to Therapeutic Innovation
This article provides a comprehensive analysis of the mechanisms underlying bacterial persister cell formation across major pathogenic species.
Breaking Bacterial Persistence: Strategies to Resensitize Dormant Cells to Conventional Antibiotics
This article provides a comprehensive review of innovative strategies to combat bacterial persister cells, a major cause of chronic infections and treatment relapse.
Substrate Control as an Anti-Persister Strategy: Disrupting Metabolic Dormancy to Combat Chronic Infections
This article explores the critical role of substrate availability in the formation and survival of bacterial persister cells, a major cause of chronic and relapsing infections.
Troubleshooting VBNC Cell Detection: Overcoming False Results and Optimizing Methods for Biomedical Research
The accurate detection of viable but non-culturable (VBNC) cells is critical for assessing pathogenic threats, evaluating sterilization efficacy, and ensuring the potency of live biotherapeutics.
Therapeutic Strategies for Disrupting Toxin-Antitoxin Module Function: From Mechanism to Novel Antimicrobials
Toxin-antitoxin (TA) systems are ubiquitous genetic modules in pathogenic bacteria, crucial for stress response, persistence, and biofilm formation, making them promising targets for novel antimicrobial strategies.
Systematic Design of Periodic Antibiotic Dosing to Eradicate Bacterial Persisters
Persister cells, a dormant subpopulation of bacteria tolerant to conventional antibiotics, are a major cause of chronic and relapsing infections.